Bergapten alleviates osteoarthritis by regulating the ANP 32A/ ATM signaling pathway
نویسندگان
چکیده
منابع مشابه
The mTOR pathway negatively controls ATM by up-regulating miRNAs.
The ataxia telangiectasia mutated (ATM) checkpoint is the central surveillance system that maintains genome integrity. We found that in the context of childhood sarcoma, mammalian target of rapamycin (mTOR) signaling suppresses ATM by up-regulating miRNAs targeting ATM. Pharmacological inhibition or genetic down-regulation of the mTOR pathway resulted in increase of ATM mRNA and protein both in...
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Progression from G(1) to S is essential for polyomavirus DNA replication and depends on the interaction of large T with the retinoblastoma gene product pRb. This virus-induced replication pathway is accompanied by p53 activation resembling a DNA damage response (12). We sought to determine whether this pathway depends in part on activation of the ATM (ataxia telangiectasia mutated) kinase and w...
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ژورنال
عنوان ژورنال: FEBS Open Bio
سال: 2019
ISSN: 2211-5463,2211-5463
DOI: 10.1002/2211-5463.12648